It's not possible to say which medicine is "best" for staying in bed longer because its usefulness depends on the person and the reason for rapid ejaculation. But some medicines are often used to deal with this problem. Selective serotonin reuptake inhibitors (SSRIs), like sertraline or paroxetine, are sometimes given to men who don't need them to delay ejaculation. These drugs change the amount of serotonin in the brain, which can help you wait longer to ejaculate. Topical anesthetics, such as lidocaine or benzocaine, can also be used to numb the penis and make it take longer to ejaculate. But it's important to talk to a doctor or nurse before taking any medicine to make sure it's safe and right for you and to talk about any possible side effects and other treatment choices.